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A Little Riboflavin Goes a Long Way for Migraine Relief
Supplementing with relatively small amounts of riboflavin (vitamin B2) may reduce the
frequency and severity of migraines in chronic sufferers,
reports a study in Headache (2004;44:885'90). Previous studies
showing that riboflavin can prevent migraines used 400 mg per
day, which is at least 200 times the amount in a typical diet.
In the new study, 25 mg per day appeared to be effective.
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 Riboflavin was originally considered for migraine prevention
because researchers observed that migraine sufferers tend to
have impaired energy production in brain cells, which riboflavin
has the potential to enhance as it is a component of a key
substance involved in the body's energy production. Another
nutrient important for producing energy (magnesium) has already
been shown to reduce migraine recurrence. In earlier studies
with riboflavin, a very high dose was chosen, presumably to give
the vitamin the best chance of working. While riboflavin does
not appear to cause any significant adverse effects even at high
doses, it is possible that taking large amounts of any single
nutrient might cause subtle imbalances in body chemistry. For
that reason, if lower doses are equally effective, they are
preferable to higher amounts.
Fifty-two people suffering from recurrent migraines participated
in the three-month study. They were randomly assigned to receive
either a daily combination of riboflavin (400 mg), magnesium
(300 mg), and the herb feverfew (100 mg), or 25 mg of riboflavin
per day. Each of the three components of the combination product
has been shown in earlier research to reduce the recurrence rate
of migraines. A positive response was defined as a reduction in
the frequency of migraines by 50% or more. Forty-two percent of
participants responded to combination therapy and 44% responded
to low-dose riboflavin. In addition, the average headache
severity and the number of days with tension headaches decreased
significantly in the low-dose-riboflavin group, but not in the
group receiving combination therapy.
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Because there was no control group in the new study, one cannot
rule out the possibility that the beneficial effects of low-dose
riboflavin were due to a placebo effect. However, the
researchers considered that possibility unlikely, because the
effects of riboflavin were greater than those found with a
placebo in previous migraine studies.
In addition to riboflavin, magnesium, and feverfew, coenzyme Q10
has been found in one preliminary trial to reduce the recurrence
rate of migraines. Dietary factors also appear to be important
migraine triggers in susceptible people. For some,
tyramine-containing foods such as certain wines and aged cheeses
are the main offenders. For others, allergic reactions to common
foods such as wheat, oranges, egg, coffee, tea, and beef seem to
be the main triggers.
About the author:
For more Vitamin Information and other Vitamin Articles, visit
Vitamin Herb
University.
Alan R. Gaby, MD is an expert in nutritional therapies. He is
the author of Preventing and Reversing Osteoporosis (Prima,
1994), and co-author of The Natural Pharmacy, 2nd Edition
(Healthnotes, Three Rivers Press, 1999.
Donald Roberts
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